Solved paper of 4th year special pathology GIT

BOLD OPTIONS are correct answers q1.which is the most common site of metastasis of colorectal carcinoma ? a.bones b.liver c.regional lymph nodes d.kidney Q2.regarding colorectal carcinoma .which is the the most appropriate statement? a.carcinoma of proximal colon are annular lesions b.polypoid, exophytic masses are abundant in proximal colon cancer c.polypoid ,exophytic masses are abundant in distal colon cancer d.distal colon cancer rarely cause obstruction Q3.along with colorectal carcinoma ,familial adenomatous polyposis is also associated with which extraintestinal manifestation ? a.pulmonary eosinophilia b.pancreatic carcinoma c.hypertrophy of retinal pigment d.seborrhic keratitis Q4.A 70 year old man diagnosed with colorectal carcinoma ,after some days noticed some improvement using NSAID because? a.of its non-steroidal effect b.it causes inhibition of COX2 c.of its analgesic effect d.it causes production of PGE2 Q5.Mutation in the following gene causes colorectal carcinoma? a.APC/E catenin b.K-RAS /mismatch repair c.DNA mismatch repair d.APC/B (beta) catenin mismatch repair gene Q6.Appendicitis is caused due to obstruction caused by all of the following except : a.feacalith b.gallstone c.villous protrusion d.oxyuriaisis vermicularis Q7.the following feature characterizes acute appendicitis : a.neutrophilic infiltration of muscularis propria b.lymphocyte aggregates in appendical lumen c.antigen-antibody reaction against mucosal cells of appendix d.formation of villous projections Q8.which of the following diseases presents the symptoms like appendicitis making the diagnosis difficult ? a.peptic ulcer b.meckel's diverticulitis c.carcinoma of colon d.ruptured ovarian follicle at ovulation e.both 'b' and 'd' q9.select the correct statement about the tumors of appendix : a.cystadenomas are locally malignant tumors b.mucocele is a precancerous condition c.carcinoids are the least common tumors in appendix d.when peritoneal cavity fills with mucus from an invading cystadenocarcinoma ,it is pseudomyxoma peritoni Q10.choose the correct about morphology of appendicitis a.hemorrhagic green ulceration and green black gangrenous mucosa shows acute gangrenous appendicitis b.normal mucosa is turned bluish in case of appendicitis due to congestion c.no presence of ulceration and foci in accute suppurative appendicitis

SOLVED PAPER of third Year MBBS- BIOCHEMISTRY- "Mechanisms of action of hormones

Q1 Grave's disease is associated with which hormone a) Thyroid hormones b) Androgens c) Catecholamines d) Pituitary hormones e) None of them Q2 The normal daily intake of iodide is a) 200-600 µg b) 300-700 µg c) 100-200 µg d) 400-500 µg e) None of these Q3 Regarding T3 a) T3 appears to be major thyroid hormone metabollicaly b) Although the circulating levels of T3 are much lower than the corresponding T4 levels c) T3 is 3-5 times more active than T4 d) T3 is loosely bounded to serum proteins e) All of these Q4 Clinical features of hyperthyroidism include a) Goitre, heat intolerance, weight loss and tachycardia b) Goitre, tachycardia and cold intolerance c) Exophthalmos, goiter, tachycardia and loss of appetite d) Exophthalmos, goiter and obesity e) None of these Q5 All hormons increased the no of prolactin receptors on the mammary cell membranne,except a) Estrogen b) Thyroid hormone c) Glucocorticoides d) Progesterone e) None of these Q6 Vasopressin and oxytocin circulate unbound to proteins and have very short plasma half lives, on the order of a) 1-2 minutes b) 2-4 minutes c) 5-8 minutes d) 10-12 minutes Q7 Reverse T3 is a) A synthetic compound given counter the effectsof T3 b) Formed from T4 but has no hormone function c) Formed by isomerisation of T3 d) Formed from T4 and has hormone function e) All of them Q8 Activated phospholipase C acts on a) Phosphatidyl inositol-4, 5-biphosphate b) Inositol-1, 4, 5-triphosphate c) Protein kinase C d) Pl-3 kinase e) none of these Q9 Which of the following does not act via adenylyl cylcase pathway a) GHRH b) CRH c) Prolactin d) Erythropietin e) Both C and D Q10 Tissue level of cyclic AMP can be influenced by a) Hormones b) Nicotinic acid c) Imidazole d) Methyl xanthine e) All of them